Onder andere met: Ellen Burstyn (Chris MacNeil), Max von Sydow (Father Lancaster Merrin), Jason Miller (Father Damien Karras), Lee J. Cobb (Lieutenant William Kinderman), Kitty Winn (Sharon Spencer), Jack MacGowran (Burke Dennings), Linda Blair (Regan Teresa MacNeil), Reverend William O`Malley (Father Dyer), Barton Heyman (Dr. Klein), Peter Masterson (Dr. Barringer, Clinic Director (as Pete Masterson)), Rudolf Schündler (Karl), Gina Petrushka (Willi), Robert Symonds (Dr. Taney), Arthur Storch (Psychiatrist), Reverend Thomas Bermingham (Tom,   President of University)