Onder andere met: Colin Farrell (Alexander), Anthony Hopkins (Old Ptolemy), David Bedella (Scribe), Jessie Kamm (Child Alexander), Angelina Jolie (Olympias), Val Kilmer (Philip), Fiona O`Shaughnessy (Nurse), Connor Paolo (Young Alexander), Patrick Carroll (Young Hephaistion), Brian Blessed (Wrestling Trainer), Peter Williamson (Young Nearchus), Morgan Christopher Ferris (Young Cassander), Robert Earley (Young Ptolemy), Aleczander Gordon (Young Perdiccas), Christopher Plummer (Aristotle), Gary Stretch (Cleitus), Jared Leto (Hephaistion), Jonathan Rhys Meyers (Cassander), Rosario Dawson (Roxane)