Onder andere met: Tom Hanks (Viktor Navorski), Catherine Zeta-Jones (Amelia Warren), Stanley Tucci (Frank Dixon), Diego Luna (Enrique Cruz), Barry Shabaka Henley (Ray Thurman), Zoe Saldana (Officer Delores Torres), Eddie Jones (Salchak), Michael Nouri (Max), Guillermo Díaz (Bobby Alima), Stephen Mendel (First class steward), Valeri Nikolayev (Milodragovich), Sasha Spielberg (Lucy), Carlease Burke (Brookstone manager), Dan Finnerty (Discovery store manager), Matt Holland (Ramada Inn clerk), Carl Alacchi (Passenger), Benny Golson (Benny Golson), Mark Ivanir (Taxi driver Goran), Chi McBride (Mulroy)