Onder andere met: Keanu Reeves (John Constantine), Rachel Weisz (Angela Dodson/Isabel Dodson), Shia LaBeouf (Chas), Djimon Hounsou (Midnite), Max Baker (Beeman), Pruitt Taylor Vince (Father Hennessy), Gavin Rossdale (Balthazar), Tilda Swinton (Gabriel), Peter Stormare (Satan), Jesse Ramirez (Scavenger), José Zúñiga (Detective Weiss (as Jose Zuniga)), Francis Guinan (Father Garret), Larry Cedar (Vermin Man), April Grace (Dr. Leslie Archer), Suzanne Whang (Mother)