Onder andere met: Uma Thurman (The Bride), David Carradine (Bill), Lucy Liu (O-Ren Ishii (archive footage)), Vivica A. Fox (Vernita Green (archive footage)), Chia Hui Liu (Pai Mei (as Gordon Liu)), Michael Madsen (Budd), Daryl Hannah (Elle Driver), Michael Parks (Esteban Vihaio), Bo Svenson (Reverend Harmony), Jeannie Epper (Mrs. Harmony), Stephanie L. Moore (Joleen), Shana Stein (Erica), Caitlin Keats (Janeen), Christopher Allen Nelson (Tommy Plympton (as Chris Nelson)), Samuel L. Jackson (Rufus)