Onder andere met: Brad Pitt (Detective David Mills), Morgan Freeman (Detective Lt. William Somerset), Gwyneth Paltrow (Tracy Mills), Kevin Spacey (John Doe), R. Lee Ermey (Police Captain), Andrew Kevin Walker (Dead Man (as Andy Walker)), Daniel Zacapa (Detective Taylor), John Cassini (Officer Davis), Bob Mack (Gluttony Victim), Peter Crombie (Dr. O`Neill), Reg E. Cathey (Coroner), George Christy (Workman), Endre Hules (Cab Driver), Hawthorne James (George, Library Night Guard), William Davidson (Library Guard (as Roscoe Davidson)), Richard Roundtree (Dist. Atty. Martin Talbot)