Onder andere met: Harvey Keitel (Jacob Fuller), George Clooney (Seth Gecko), Quentin Tarantino (Richard Gecko), Juliette Lewis (Kate Fuller), Ernest Liu (Scott Fuller), Salma Hayek (Santanico Pandemonium), Cheech Marin (Border Guard/Chet Pussy/Carlos), Danny Trejo (Razor Charlie), Tom Savini (Sex Machine), Fred Williamson (Frost), Michael Parks (Texas Ranger Earl McGraw), Brenda Hillhouse (Hostage Gloria Hill), John Saxon (FBI Agent Stanley Chase), Marc Lawrence (Old Timer Motel Owner), Kelly Preston (Newscaster Kelly Houge)