Onder andere met: Ethan Hawke (Vincent Freeman), Uma Thurman (Irene Cassini), Jude Law (Jerome Eugene Morrow), Gore Vidal (Director Josef), Xander Berkeley (Dr. Lamar), Jayne Brook (Marie Freeman), Elias Koteas (Antonio Freeman), Maya Rudolph (Delivery nurse), Una Damon (Head nurse), Elizabeth Dennehy (Preschool teacher), Blair Underwood (Geneticist), Mason Gamble (Vincent Freeman, as a boy), Vincent Nielson (Anton Freeman, as a boy), Chad Christ (Vincent Freeman, as a teen), William Lee Scott (Anton Freeman, as a teen)