Onder andere met: Gwyneth Paltrow (Polly Perkins), Jude Law (Joe `Sky Captain` Sullivan), Giovanni Ribisi (Dex Dearborn), Michael Gambon (Editor Paley), Ling Bai (Mysterious Woman (as Bai Ling)), Omid Djalili (Kaji), Laurence Olivier (Dr. Totenkopf (archive footage) (as Sir Laurence Olivier)), Angelina Jolie (Capt. Francesca `Franky` Cook), Trevor Baxter (Dr. Walter Jennings), Julian Curry (Dr. Jorge Vargas), Peter Law (Dr. Arler Kessler), Jon Rumney (German Scientist), Khan Bonfils (Creepy), Samta Gyatso (Scary), Louis Hilyer (Executive Officer)