Onder andere met: Bill Bailey (The Whale (voice)), Anna Chancellor (Questular Rontok), Warwick Davis (Marvin), Mos Def (Ford Prefect), Zooey Deschanel (Trillian), Su Elliot (Pub Customer (as Su Eliott)), Martin Freeman (Arthur Dent), Stephen Fry (Narrator/The Guide (voice)), Richard Griffiths (Jeltz (voice)), Dominique Jackson (Fook), Simon Jones (Ghostly Image), Thomas Lennon (Eddie the Computer (voice)), Mark Longhurst (Bulldozer Driver), Kelly Macdonald (Reporter), John Malkovich (Humma Kavula)