Onder andere met: Sean Connery (Captain Marko Ramius), Alec Baldwin (Jack Ryan), Scott Glenn (Commander Bartolomeo Vito `Bart` Mancuso), Sam Neill (Captain 2nd Rank Vasily Borodin), James Earl Jones (Admiral James Greer), Joss Ackland (Ambassador Andrei Lysenko), Richard Jordan (Dr. Jeffrey Pelt), Peter Firth (Political Officer Ivan Yurevich Putin - Red October), Tim Curry (Dr. Petrov), Courtney B. Vance (Sonarman 2nd Class Ronald Jones), Stellan Skarsgad (Captain Tupolev), Jeffrey Jones (Oliver Wendell `Skip` Tyler), Timothy Carhart (Bill Steiner), Larry Ferguson (Chief of the Boat Watson - USS Dallas), Fred Dalton Thompson (Rear Admiral Joshua Painter - USS Enterprise)