Onder andere met: Johnny Depp (Raoul Duke/Hunter S. Thompson), Benicio Del Toro (Dr. Gonzo/Oscar Z. Acosta), Tobey Maguire (Hitchhiker), Ellen Barkin (Waitress at North Star Cafe), Gary Busey (Highway Patrolman), Christina Ricci (Lucy), Mark Harmon (Magazine Reporter at Mint 400), Cameron Diaz (Blonde TV Reporter), Katherine Helmond (Desk Clerk at Mint Hotel), Michael Jeter (L. Ron Bumquist), Penn Jillette (Carnie Talker), Craig Bierko (Lacerda), Lyle Lovett (Road Person), Flea (Musician), Laraine Newman (Frog-Eyed Woman)

Most drugs in a movie everrrr....