Onder andere met: Dwayne Johnson (Davis Okoye), Naomie Harris (Dr. Kate Caldwell), Malin Åkerman (Claire Wyden, CEO van Energyne), Jeffrey Dean Morgan (Harvey Russell), Jake Lacy (Brett Wyden), Joe Manganiello (Burke), Marley Shelton (Dr. Kerry Atkins, wetenschapper en astronaut), P. J. Byrne (Nelson), Demetrius Grosse (Colonel Blake), Jack Quaid (Connor), Breanne Hill (Amy)