Onder andere met: Tom Holland (Peter Parker / Spider-Man), Michael Keaton (Adrian Toomes / Vulture), Robert Downey Jr. (Tony Stark / Iron Man), Marisa Tomei (May Parker), Jon Favreau (Happy Hogan), Gwyneth Paltrow (Pepper Potts), Zendaya (Michelle), Donald Glover (Aaron Davis), Jacob Batalon (Ned), Laura Harrier (Liz), Tony Revolori (Flash), Bokeem Woodbine (Herman Schultz), Tyne Daly (Anne Marie Hoag), Abraham Attah (Abe), Hannibal Buress (Coach Wilson), Kenneth Choi (Principal Morita), Angourie Rice (Betty)