Onder andere met: Tom Cruise (Nick Morton), Russell Crowe (Dr. Henry Jekyll), Annabelle Wallis (Jenny Halsey), Sofia Boutella (Ahmanet), Jake Johnson (Chris Vail), Courtney B. Vance (Colonel Greenway), Marwan Kenzari (Malik), Simon Atherton (Crusader), Stephen Thompson (First Man), James Arama (Second Man), Matthew Wilkas (Reporter), Sohm Kapila (Reporter), Selva Rasalingam (King Menehptre), Shanina Shaik (Arabian Princess), Javier Botet (Set), Neil Maskell (Dr. Whemple), Rhona Croker (Helen)