Onder andere met: Naomi Watts (Rachel Keller), Simon Baker (Max Rourke), David Dorfman (Aidan Keller), Elizabeth Perkins (Dr. Emma Temple), Gary Cole (Martin Savide), Sissy Spacek (Evelyn), Ryan Merriman (Jake), Emily VanCamp (Emily), Kelly Overton (Betsy), James Lesure (Doctor), Daveigh Chase (Samara (archive footage)), Kelly Stables (Evil Samara), Cooper Thornton (Father of Emily), Marilyn McIntyre (Mother of Emily), Jesse Burch (Male Reporter)