Onder andere met: Ryan Reynolds (Wade / Deadpool), Morena Baccarin (Vanessa), Ed Skrein (Francis / Ajax), Michael Benyaer (Warlord), Greg LaSalle (Colossus), Stefan Kapicic (Colossus (voice)), Brianna Hildebrand (Negasonic Teenage Warhead), Karan Soni (Dopinder), Style Dayne (Jeremy), Kyle Cassie (Gavin Merchant), Taylor Hickson (Meghan Orlovsky), Randal Reeder (Buck), T.J. Miller (Weasel), Isaac C. Singleton Jr. (Boothe), Jed Rees (Recruiter), Hugh Scott (David Cunningham), Gina Carano (Angel Dust), Stan Lee (Strip Club DJ), Rachel Sheen (Stripper), Rob Hayter (Bob)