Onder andere met: Chevy Chase (Clark Griswold), Beverly D'Angelo (Ellen Griswold), Randy Quaid (Cousin Eddie), Ethan Embry (Rusty Griswold), Marisol Nichols (Audrey Griswold), Miriam Flynn (Cousin Catherine), Shae D'lyn (Cousin Vicki), Wayne Newton (Wayne Newton), Siegfried Fischbacher (Himself), Roy Horn (Himself), Wallace Shawn (Marty), Sid Caesar (Mr. Ellis), Julio Oscar Mechoso (Limo Driver), Christie Brinkley (Woman in Ferrari), Juliette Brewer (Cousin Ruby Sue), Zach Moyes (Cousin Denny)