Onder andere met: Ed Helms (Rusty Griswold), Christina Applegate (Debbie Griswold), Skyler Gisondo (James Griswold), Steele Stebbins (Kevin Griswold), Chris Hemsworth (Stone Crandall), Leslie Mann (Audrey Crandall), Chevy Chase (Clark Griswold), Beverly D'Angelo (Ellen Griswold), Charlie Day (Chad), Catherine Missal (Adena), Ron Livingston (Ethan), Norman Reedus (Trucker), Keegan-Michael Key (Jack Peterson), Regina Hall (Nancy Peterson), Emyri Crutchfield (Sheila Peterson), Alkoya Brunson (Gary Peterson), Hannah Davis (Ferrari Girl), Colin Hanks (Jake), Elizabeth Gillies (Heather), Cristina Squyres (Brooke), Nadine Avola (Chelsea)