Onder andere met: Liam Neeson (Bill Marks), Julianne Moore (Jen Summers), Michelle Dockery (Nancy Hoffman), Nate Parker (Zack White), Linus Roache (Captain David McMillan), Scoot McNairy (Tom Bowen), Corey Stoll (Austin Reilly, an NYPD police officer), Lupita Nyong'o (Gwen Lloyd, a flight attendant), Anson Mount (Jack Hammond), Omar Metwally (Dr. Fahim Nasir), Jason Butler Harner (First Officer Kyle Rice, the co-pilot), Corey Hawkins (Travis Mitchell), Frank Deal (Charles Wheeler)