Onder andere met: Peter Weller (Buckaroo Banzai), John Lithgow (Lord John Whorfin / Dr. Emilio Lizardo), Ellen Barkin (Penny Priddy), Jeff Goldblum (New Jersey), Christopher Lloyd (John Bigboote), Lewis Smith (Perfect Tommy), Rosalind Cash (John Emdall), Robert Ito (Professor Hikita), Pepe Serna (Reno Nevada), Ronald Lacey (President Widmark), Matt Clark (Secretary of Defense), Clancy Brown (Rawhide), William Traylor (General Catburd), Carl Lumbly (John Parker), Vincent Schiavelli (John O'Connor), Dan Hedaya (John Gomez)