Onder andere met: Seth Rogen (Mac Radner), Rose Byrne (Kelly Radner), Elise Vargas (Stella), Zoey Vargas (Stella), Brian Huskey (Bill Wazowkowski), Ike Barinholtz (Jimmy), Carla Gallo (Paula), Zac Efron (Teddy Sanders), Dave Franco (Pete), Halston Sage (Brooke), Christopher Mintz-Plasse (Scoonie), Jerrod Carmichael (Garf), Craig Roberts (Assjuice), Ali Cobrin (Whitney), Kira Sternbach (Brittany), Steven Michael Eich (Thumbsucker), Lisa Kudrow (Dean Carol Gladstone), Hannibal Buress (Officer Watkins), Natasha Leggero (Prostitute)