Onder andere met: Danny Trejo (Machete), Mel Gibson (Voz), Demian Bichir (Mendez), Amber Heard (Miss San Antonio), Michelle Rodriguez (Luz), Sofía Vergara (Desdemona), Charlie Sheen (Mr. President (as Carlos Estevez)), Lady Gaga (La Camaleón), Antonio Banderas (El Camaleón 4), Walton Goggins (El Cameleón 1 (as Walt Goggins)), Cuba Gooding Jr. (El Camaleón 2), Vanessa Hudgens (Cereza), Alexa PenaVega (KillJoy (as Alexa Vega)), Marko Zaror (Zaror), Tom Savini (Osiris Amanapur), William Sadler (Sheriff Doakes), Jessica Alba (Sartana (uncredited))