Onder andere met: Anthony Hopkins (Hannibal Lecter), Edward Norton (Will Graham), Ralph Fiennes (s Francis Dolarhyde), Harvey Keitel (Jack Crawford), Emily Watson (Reba McClane), Mary-Louise Parker (Molly Graham), Philip Seymour Hoffman (Freddy Lounds), Frank Whaley (Ralph Mandy), Anthony Heald (Frederick Chilton), Ken Leung (Lloyd Bowman), Frankie Faison (Barney Matthews), Ellen Burstyn (voice of Grandma Dolarhyde), Tyler Patrick Jones (Josh Graham)