Onder andere met: Robert Downey Jr. (Tony Stark), Gwyneth Paltrow (Pepper Potts), Don Cheadle (Colonel James Rhodes), Guy Pearce (Aldrich Killian), Rebecca Hall (Maya Hansen), Jon Favreau (Happy Hogan), Ben Kingsley (Trevor Slattery), James Badge Dale (Savin), Stephanie Szostak (Brandt), Paul Bettany (Jarvis (voice)), William Sadler (President Ellis), Dale Dickey (Mrs. Davis), Ty Simpkins (Harley Keener), Miguel Ferrer (Vice President Rodriguez), Xueqi Wang (Doctor Wu), Shaun Toub (Ho Yinsen)