Onder andere met: Nicolas Cage (Johnny Blaze / Ghost Rider), Eva Mendes (Roxanne Simpson), Wes Bentley (Blackheart), Sam Elliott (Caretaker), Donal Logue (Mack), Peter Fonda (Mephistopheles), Matt Long (Young Johnny Blaze), Raquel Alessi (Young Roxanne Simpson), Brett Cullen (Barton Blaze), Gibson Nolte (Stuart), Laurence Breuls (Gressil), Daniel Frederiksen (Wallow), Mathew Wilkinson (Abigor), Kirstie Hutton (Amy Page), Peter Callan (Station Master), David Roberts (Captain Dolan), Arthur Angel (Officer Edwards)