Onder andere met: Robert De Niro (Jack Byrnes), Ben Stiller (Greg Focker), Dustin Hoffman (Bernie Focker), Barbra Streisand (Roz Focker), Blythe Danner (Dina Byrnes), Teri Polo (Pam Byrnes), Owen Wilson (Kevin Rawley), Spencer Pickren (Little Jack), Bradley Pickren (Little Jack), Alanna Ubach (Isabel), Ray Santiago (Jorge Villalobos), Tim Blake Nelson (Officer LeFlore), Shelley Berman (Judge Ira), Kali Rocha (Flight Attendant), Dorie Barton . (Airline Clerk)