Onder andere met: Whoopi Goldberg (Deloris Van Cartier / Sister Mary Clarence), Kathy Najimy (Sister Mary Patrick), Barnard Hughes (Father Maurice), Mary Wickes (Sister Mary Lazarus), James Coburn (Mr. Crisp), Michael Jeter (Father Ignatius), Wendy Makkena (Sister Mary Robert), Sheryl Lee Ralph (Florence Watson), Robert Pastorelli (Joey Bustamente), Thomas Gottschalk (Father Wolfgang), Maggie Smith (Mother Superior), Lauryn Hill (Rita Louise Watson), Brad Sullivan (Father Thomas), Alanna Ubach (Maria), Ryan Toby (Westley Glen 'Ahmal' James), Jennifer Love Hewitt (Margaret (as Jennifer 'Love' Hewitt))