Onder andere met: Mark Wahlberg (John Bennett), Mila Kunis (Lori Collins), Seth MacFarlane (Ted (voice)), Joel McHale (Rex), Giovanni Ribisi (Donny), Patrick Warburton (Guy), Matt Walsh (Thomas), Jessica Barth (Tami-Lynn), Aedin Mincks (Robert), Bill Smitrovich (Frank), Patrick Stewart (Narrator (voice)), Norah Jones (Herself), Sam J. Jones (Himself), Tom Skerritt (Himself), Bretton Manley (Young John), John Viener (Alix), Laura Vandervoort (Tanya), Ginger Gonzaga (Gina), Jessica Stroup (Tracy), Melissa Ordway (Michelle), Kristina Ellery (Heavenly), Katelyn Lorren (Cherene), Chanty Sok (Angelique), Sarah Fischer (Sauvignon Blanc)