Onder andere met: James Stewart (George Bailey), Donna Reed (Mary Hatch), Lionel Barrymore (Henry F. Potter), Thomas Mitchell (Uncle Billy Bailey), Henry Travers (Clarence), Beulah Bondi (Ma Bailey), Frank Faylen (Ernie Bishop), Ward Bond (Bert), Gloria Grahame (Violet Bick), H.B. Warner (Mr. Gower), Frank Albertson (Sam Wainwright), Todd Karns (Harry Bailey), Samuel S. Hinds (Peter Bailey), Mary Treen (Cousin Tilly), Virginia Patton (Ruth Dakin Bailey), Charles Williams (Cousin Eustace), Sarah Edwards (Mrs. Hatch), William Edmunds (Giuseppe Martini), Lillian Randolph (Annie), Argentina Brunetti (Mrs. Martini), Sheldon Leonard (Nick)