Onder andere met: Marion Cotillard (Dr. Leonora Orantes), Laurence Fishburne (Dr. Ellis Cheever), Kate Winslet (Dr. Erin Mears), Gwyneth Paltrow (Beth Emhoff), Matt Damon (Mitch Emhoff), Jude Law (Alan Krumwiede), Jennifer Ehle (Dr. Ally Hextall), Sanaa Lathan (vrouw van Ellis Cheever), Demetri Martin (Dr. David Eisenberg), Elliott Gould (Dr. Ian Sussman), Amr Waked (Rafik), Chin Han (Sun Feng), Daria Strokous (Irina), Monique Gabriela Curnen (Lorraine Vasquez), Griffin Kane (Clark Morrow), John Hawkes (Roger)