Onder andere met: Noomi Rapace (Elizabeth Shaw), Michael Fassbender (David), Charlize Theron (Meredith Vickers), Idris Elba (Janek), Guy Pearce (Peter Weyland), Logan Marshall-Green (Charlie Holloway), Sean Harris (Fifield), Rafe Spall (Millburn), Emun Elliott (Chance), Benedict Wong (Ravel), Kate Dickie (Ford), Patrick Wilson (Shaw's Father), Giannina Facio (Shaw's Mother), Lucy Hutchinson (Young Shaw), Ian Whyte (Last Engineer)