Onder andere met: Gary Oldman (George Smiley), Colin Firth (Bill Haydon), Tom Hardy (Ricki Tarr), Mark Strong (Jim Prideaux), Ciarán Hinds (Roy Bland), Benedict Cumberbatch (Peter Guillam), David Dencik (Toby Esterhase), Stephen Graham (Jerry Westerby), Simon McBurney (Oliver Lacon), Toby Jones (Percy Alleline), John Hurt (Control), Svetlana Khodchenkova (Irina), Kathy Burke (Connie Sachs), Roger Lloyd-Pack (Mendel), Christian McKay (Mackelvore), Konstantin Khabensky (Polyakov)