Onder andere met: Denzel Washington (Frank Lucas), Russell Crowe (Richie Roberts), Chiwetel Ejiofor (Huey Lucas), Cuba Gooding Jr. (Nicky Barnes), Josh Brolin (Detective Trupo), Lymari Nadal (Eva Kendo Lucas), Ted Levine (Lou Toback), Ruby Dee (Mama Lucas), Roger Guenveur Smith (Nate), John Hawkes (Freddie Spearman), RZA (Moses Jones), Idris Elba (Tango), KaDee Strickland (Roberts' advocate), Kevin Corrigan (Campizi), Joe Morton (Charlie Williams), Carla Gugino (Laurie Roberts), Armand Assante (Dominic Cattano), John Ortiz (Rivera), Yul Vasquez (Abruzzo)