Onder andere met: Rachel Weisz (Hypatia), Max Minghella (Davus), Oscar Isaac (Orestes), Sami Samir (Cyrillus), Manuel Cauchi (Theophilus ), Ashraf Barhom (Ammonius), Michael Lonsdale (Theon , father of Hypatia), Rupert Evans (Synesius), Homayoun Ershadi (Aspasius, the old slave), Charles Thake (Hesychius), Amber Rose Revah (Sidonia, the Christian slave), Harry Borg . (Evagrius)