Onder andere met: Steve Carell (Gru), Jason Segel (Vector), Russell Brand (Dr. Nefario), Julie Andrews (Gru's Mom), Will Arnett (Mr. Perkins), Kristen Wiig (Miss Hattie), Miranda Cosgrove (Margo), Dana Gaier (Edith), Elsie Fisher (Agnes), Pierre Coffin (Tim the Minion / Bob the Minion / Mark the Minion / Phil the Minion / Stuart the Minion), Chris Renaud (Dave the Minion), Jemaine Clement (Jerry the Minion), Jack McBrayer (Carnival Barker / Tourist Dad), Danny McBride (Fred McDade), Mindy Kaling (Tourist Mom)