Onder andere met: Chevy Chase (Clark Griswold), Beverly D'Angelo (Ellen Griswold), Juliette Lewis (Audrey Griswold), Johnny Galecki (Russell 'Rusty' Griswold), John Randolph (Clark Wilhelm Griswold, Sr.), Diane Ladd (Nora Griswold), E.G. Marshall (Art Smith), Doris Roberts (Frances Smith), Randy Quaid (Eddie Johnson), Miriam Flynn (Catherine Johnson), Cody Burger (Rocky Johnson), Ellen Hamilton Latzen (Ruby Sue Johnson), William Hickey (Uncle Lewis), Mae Questel (Aunt Bethany), Sam McMurray (Bill), Nicholas Guest (Todd Chester), Julia Louis-Dreyfus (Margo Chester)