Onder andere met: Robert Downey Jr. (Tony Stark), Don Cheadle (Lt. Col. James 'Rhodey' Rhodes), Scarlett Johansson (Natalie Rushman / Natasha Romanoff), Gwyneth Paltrow (Pepper Potts), Sam Rockwell (Justin Hammer), Mickey Rourke (Ivan Vanko), Samuel L. Jackson (Nick Fury), Clark Gregg (Agent Coulson), John Slattery (Howard Stark), Garry Shandling (Senator Stern), Paul Bettany (Jarvis (voice)), Kate Mara (U.S. Marshal), Leslie Bibb (Christine Everhart), Jon Favreau (Happy Hogan), Christiane Amanpour (Herself), Jasmine Dustin (Watermelon Girl)