Onder andere met: Danny Trejo (Machete), Robert De Niro (Senator McLaughlin), Jessica Alba (Sartana), Steven Seagal (Torrez), Michelle Rodriguez (Luz), Jeff Fahey (Booth), Cheech Marin (Padre), Don Johnson (Lt. Von Jackson), Shea Whigham (Sniper), Lindsay Lohan (April), Cheryl Chin (Torrez Henchwoman), Daryl Sabara (Julio), Electra Avellan (Nurse Mona), Gilbert Trejo (Jorge), Elise Avellan (Nurse Lisa), Ara Celi (Reporter), Tom Savini (Osiris Ampanpour), Billy Blair (Von's Henchman), Felix Sabates (Doc Felix), Marci Madison (Nurse Fine), Vic Trevino (Federale Officer)