Onder andere met: Al Pacino (Benjamin `Lefty` Ruggiero), Johnny Depp (Donnie Brasco/Joseph D. `Joe` Pistone), Michael Madsen (Sonny Black), Bruno Kirby (Nicky), James Russo (Paulie), Anne Heche (Maggie Pistone), Zeljko Ivanek (Tim Curley), Gerry Becker (Dean Blandford), Robert Miano (Sonny Red), Brian Tarantina (Bruno), Rocco Sisto (Richard `Richie` Gazzo), Zach Grenier (Dr. Berger), Walt MacPherson (Sheriff), Ronnie Farer (Annette), Terry Serpico (Strip Club Owner)