Onder andere met: Sarah Michelle Gellar (Kathryn Merteuil), Ryan Phillippe (Sebastian Valmont), Reese Witherspoon (Annette Hargrove), Selma Blair (Cecile Caldwell), Louise Fletcher (Helen Rosemond), Joshua Jackson (Blaine Tuttle), Eric Mabius (Greg McConnell), Sean Patrick Thomas (Ronald Clifford), Swoosie Kurtz (Dr. Greenbaum), Christine Baranski (Bunny Caldwell), Alaina Reed-Hall (Nurse), Deborah Offner (Mrs. Michalak), Tara Reid (Marci Greenbaum), Herta Ware (Mrs. Sugarman), Hiep Thi Le (Mai-Lee), Ginger Williams (Clorissa)