Onder andere met: Will Smith (Cassius Clay/Cassius X/Muhammad Ali), Jamie Foxx (Drew `Bundini` Brown), Jon Voight (Howard Cosell), Mario Van Peebles (Malcolm X), Ron Silver (Angelo Dundee), Jeffrey Wright (Howard Bingham), Mykelti Williamson (Don King), Jada Pinkett Smith (Sonji), Nona M. Gaye (Belinda Ali (as Nona Gaye)), Michael Michele (Veronica Porche), Joe Morton (Chauncey Eskridge), Bruce McGill (Bradley), Paul Rodriguez (Dr. Ferdie Pacheco), Barry Shabaka Henley (Herbert Muhammad), Giancarlo Esposito (Cassius Clay, Sr.)