Onder andere met: Sigourney Weaver (Ellen Ripley), Winona Ryder (Annalee Call), Dominique Pinon (Vriess), Ron Perlman (Johner), Gary Dourdan (Christie), Michael Wincott (Frank Elgyn), Kim Flowers (Sabra Hillard), Dan Hedaya (Gen. Martin Perez), J.E. Freeman (Dr. Mason Wren), Brad Dourif (Dr. Jonathan Gediman), Raymond Cruz (Vincent Distephano), Leland Orser (Larry Purvis), Carolyn Campbell (Carlyn Williamson (Anesthesiologist)), Marlene Bush (Scientist), David St. James (Surgeon)