Onder andere met: Sam Worthington (Jake Sully), Zoe Saldana (Neytiri), Sigourney Weaver (Dr. Grace Augustine), Stephen Lang (Colonel Miles Quaritch), Michelle Rodriguez (Trudy Chacon), Giovanni Ribisi (Parker Selfridge), Joel Moore (Norm Spellman (as Joel David Moore)), CCH Pounder (Moat), Wes Studi (Eytukan), Laz Alonso (Tsu'tey), Dileep Rao (Dr. Max Patel), Matt Gerald (Corporal Lyle Wainfleet), Sean Anthony Moran (Private Fike), Jason Whyte (Cryo Vault Med Tech), Scott Lawrence (Venture Star Crew Chief)