Onder andere met: Edward Asner (Carl Fredricksen (voice) (as Ed Asner)), Christopher Plummer (Charles Muntz (voice)), Jordan Nagai (Russell (voice)), Bob Peterson (Dug / Alpha (voice)), Delroy Lindo (Beta (voice)), Jerome Ranft (Gamma (voice)), John Ratzenberger (Construction Foreman Tom (voice)), David Kaye (Newsreel Announcer (voice)), Elie Docter (Young Ellie (voice)), Jeremy Leary (Young Carl (voice)), Mickie McGowan (Police Officer Edith (voice)), Danny Mann (Construction Worker Steve (voice)), Donald Fullilove (Nurse George (voice)), Jess Harnell (Nurse AJ (voice)), Josh Cooley (Omega (voice))