Onder andere met: Ellen Page (Juno MacGuff), Michael Cera (Paulie Bleeker), Jennifer Garner (Vanessa Loring), Jason Bateman (Mark Loring), Allison Janney (Brenda 'Bren' MacGuff), J.K. Simmons (Mac MacGuff), Olivia Thirlby (Leah), Eileen Pedde (Gerta Rauss), Darla Vandenbossche (Bleeker's Mom), Valerie Tian (Su-Chin Qah), Emily Perkins (Punk Receptionist)