Onder andere met: Nicolas Cage (Cameron Poe), John Cusack (U.S. Marshal Vince Larkin), John Malkovich (Cyrus `The Virus` Grissom), Ving Rhames (Nathan `Diamond Dog` Jones), Nick Chinlund (William `Billy Bedlam` Bedford), Steve Buscemi (Garland `The Marietta Mangler` Greene), Colm Meaney (DEA Agent Duncan Malloy), Rachel Ticotin (Guard Sally Bishop), Dave Chappelle (Joe `Pinball` Parker), Mykelti Williamson (Mike `Baby-O` O`Dell), Danny Trejo (Johnny `Johnny-23` Baca), M.C. Gainey (Swamp Thing), Steve Eastin (Guard Falzon), Renoly Santiago (Ramon `Sally-Can`t Dance` Martinez (as Renoly)), Monica Potter (Tricia Poe)