Onder andere met: Guy Pearce (Leonard Shelby), Carrie-Anne Moss (Natalie), Joe Pantoliano (Teddy Gammell), Mark Boone Junior (Burt Hadley), Russ Fega (Waiter), Jorja Fox (Catherine Shelby), Stephen Tobolowsky (Sammy Jankis), Harriet Sansom Harris (Mrs. Jankis), Thomas Lennon (Doctor), Callum Keith Rennie (Dodd), Kimberly Campbell (Blonde Whore), Marianne Muellerleile (Emma the Tattooist), Larry Holden (Jimmy Grantz)