Onder andere met: Nicolas Cage (Charlie Kaufman/Donald Kaufman), Meryl Streep (Susan Orlean), Chris Cooper (John Laroche), Cara Seymour (Amelia Kavan), Tilda Swinton (Valerie Thomas), Ron Livingston (Marty Bowen), Brian Cox (Robert McKee), Maggie Gyllenhaal (Caroline Cunningham), Jim Beaver (Ranger Tony), Judy Greer (Alice the Waitress), Litefoot (Russell (as G. Paul Davis)), Doug Jones (Augustus Margary), Jay Tavare (Matthew Osceola), Stephen Tobolowsky (Ranger Steve Neely (scenes deleted)), Roger Willie (Randy)