Onder andere met: Ron Perlman (Hellboy), Selma Blair (Liz Sherman), Doug Jones (Abe Sapien / The Chamberlain / The Angel of Death), James Dodd (Johann Krauss), Jeffrey Tambor (Tom Manning), John Alexander (Johann Krauss), Luke Goss (Prince Nuada), Anna Walton (Princess Nuala), Seth MacFarlane (Johann Krauss (voice)), John Hurt (Professor Trevor 'Broom' Bruttenholm), Brian Steele (Mr. Wink / Cronie Troll / Cathedral Head / Fragglewump), Roy Dotrice (King Balor)